Tyrosine Kinase Signal Modulation: A Matter of H2O2 Membrane Permeability?
نویسندگان
چکیده
منابع مشابه
Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase.
The capsaicin receptor TRPV1 is a nonselective cation channel that is expressed in sensory neurons. In this study, we examined the role of the nonreceptor cellular tyrosine kinase c-Src kinase in the modulation of the rat TRPV1. Capsaicin-induced currents in identified colonic dorsal root ganglion neurons were blocked by the c-Src kinase inhibitor PP2 and enhanced by the tyrosine phosphatase in...
متن کاملReceptor tyrosine kinase-GPCR signal complexes.
The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth factor and/or S1P/LPA and provides a mechanism for more efficient activation (due ...
متن کاملSignal modulation in cold-dark-matter detection.
If weakly interacting massive.particles (WIMPS) are the dark matter in the galactic halo, they may be detected in low background ionization detectors now operating or with low temperature devices under development. In detecting WIMPS of low msss or WIMPS with spin-dependent nuclear interactions (e.g., photinos), a principal technical difficulty appears to be achieving very low thresholds (5 O(k...
متن کاملp21-activated kinase regulates endothelial permeability through modulation of contractility.
Endothelial cells lining the vasculature have close cell-cell associations that maintain separation of the blood fluid compartment from surrounding tissues. Permeability is regulated by a variety of growth factors and cytokines and plays a role in numerous physiological and pathological processes. We examined a potential role for the p21-activated kinase (PAK) in the regulation of vascular perm...
متن کاملModulation of Kv1.5 currents by protein kinase A, tyrosine kinase, and protein tyrosine phosphatase requires an intact cytoskeleton.
The regulation of cardiac delayed rectifier potassium (Kv) currents by cAMP-dependent protein kinase (PKA) contributes to the control of blood pressure and heart rate. We investigated the modulation by PKA and protein phosphatases of cloned Kv1.5 channels expressed in Xenopus laevis oocytes. Exposure of oocytes to activators of PKA (100 nM forskolin, 1 mM 8-bromo-cAMP, or 1 mM 3-isobutyl-1-meth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2013
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5330